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Portishead singles. The aim of this paper is to externally validate the hypothesis G og clip1 Barbare et al. The methods of the CLIP-1 trial have been detailed elsewhere [ 1 ]. CLIP-1 multicenter randomised trial had a pragmatic approach with large and simple inclusion criteria: Differently from other studies, this trial was not limited to patients with advanced disease, thus we had the opportunity to G og clip1 the possible efficacy of treatment with tamoxifen even in potentially curable subjects [ 3 ].

Pornhub milf Watch SEX Movies Ebony sexi. Amazing Featured Video. See Spidey's ally turn on him. Web Warriors" Videos. Part Four" - Clip 1 0: Contest of Champions: Part Three - Clip 1 1: Part Two - Clip 1 0: Part One - Clip 1 0: Part Four" Clip 1 1: Part Three" Clip 1 1: Part Two" Clip 1 1: Part One" Clip 2 1: Part One" Clip 1 1: Part Three" Clip 1: The 1st-century Jewish historian Josephus identified the Gog and Magog people as Scythians , horse-riding barbarians from around the Don and the Sea of Azov. Josephus recounts the tradition that Gog and Magog were locked up by Alexander the Great behind iron gates in the "Caspian Mountains", generally identified with the Caucasus Mountains. This legend must have been current in contemporary Jewish circles by this period, coinciding with the beginning of the Christian Era. The Pseudo-Methodius , written originally in Syriac, is considered the source of Gog and Magog tale incorporated into Western versions of the Alexander Romance. Pseudo-Methodius 7th century [54] is the first source in the Christian tradition for a new element: This Gog and Magog legend is not found in earlier versions of the Alexander romance of Pseudo-Callisthenes, whose oldest manuscript dates to the 3rd century, [l] but an interpolation into recensions around the 8th century. Gog and Magog appear in somewhat later Old French versions of the romance. Gog and Magog also appear in Thomas de Kent 's Roman de toute chevalerie c. A condensed account occurs in a derivative work, the Middle English King Alisaunder vv. The Gog and Magog are not only human flesh-eaters, but illustrated as men "a notably beaked nose" in examples such as the "Henry of Mainz map", an important example of mappa mundi. Early Christian writers e. Eusebius frequently identified Gog and Magog with the Romans and their emperor. As one nomadic people followed another on the Eurasian steppes, so the identification of Gog and Magog shifted. In the 9th and 10th centuries these kingdoms were identified by some with the lands of the Khazars , a Turkic people who had converted to Judaism and whose empire dominated Central Asia—the 9th-century monk Christian of Stavelot referred to Gazari, said of the Khazars that they were "living in the lands of Gog and Magog" and noted that they were "circumcised and observing all [the laws of] Judaism". After the Khazars came the Mongols , seen as a mysterious and invincible horde from the east who destroyed Muslim empires and kingdoms in the early 13th century; kings and popes took them for the legendary Prester John , marching to save Christians from the Saracens , but when they entered Poland and Hungary and annihilated Christian armies a terrified Europe concluded that they were "Magogoli", the offspring of Gog and Magog, released from the prison Alexander had constructed for them and heralding Armageddon. Europeans in Medieval China reported findings from their travels to the Mongol Empire. The Tartar Relation , an obscure account of Friar Carpini's s journey to Mongolia, is unique in alleging that these Caspian Mountains in Mongolia, "where the Jews called Gog and Magog by their fellow countrymen are said to have been shut in by Alexander", were moreover purported by the Tartars to be magnetic, causing all iron equipment and weapons to fly off toward the mountains on approach. In fact, Gog and Magog were held by the Mongol to be their ancestors, at least by some segment of the population. As traveler and Friar Riccoldo da Monte di Croce put it in c. Some time around the 12th century, the Ten Lost Tribes of Israel came to be identified with Gog and Magog; [88] possibly the first to do so was Petrus Comestor in Historica Scholastica c. While the confounding Gog and Magog as confined Jews was becoming commonplace, some, like Riccoldo or Vincent de Beauvais remained skeptics, and distinguished the Lost Tribes from Gog and Magog. He also addressed many minds Westerners or otherwise [93] being credulous of the notion that Mongols might be Captive Jews, but after weighing the pros and cons, he concluded this was an open question. The Flemish Franciscan friar William of Rubruck , who was first-hand witness to Alexander's supposed wall in Derbent on the shores of the Caspian Sea in , [w] identified the people the walls were meant to fend off only vaguely as "wild tribes" or "desert nomads", [x] [97] but one researcher made the inference Rubruck must have meant Jews, [y] and that he was speaking in the context of "Gog and Magog". The author of the Travels of Sir John Mandeville , a 14th-century best-seller, said he had found these Jews in Central Asia where as Gog and Magog they had been imprisoned by Alexander, plotting to escape and join with the Jews of Europe to destroy Christians. He agrees to build it for them, but warns that when the time comes Last Age , Allah will remove the barrier and Yajuj and Majuj will swarm through. The early Muslim traditions were summarised by Zakariya al-Qazwini d. Gog and Magog, he says, live near to the sea that encircles the Earth and can be counted only by God; they are only half the height of a normal man, with claws instead of nails and a hairy tail and huge hairy ears which they use as mattress and cover for sleeping. They break for the night saying tomorrow we will finish, and each night God restores it. Then one day, as they stop scratching for the night, one will say tomorrow we will finish God Willing, and in the morning, it is not restored as with everything night. When they do break through they will be so numerous that "their vanguard is in Syria and their rear in Khorasan ". Various nations and peoples in history were identified as Ya'juj and Ma'juj. At one point, it was the Turks, who threatened Baghdad and northern Iran; [] later, when the Mongols destroyed Baghdad in , it was they who were Gog and Magog. It has been narrated from Ibn Abbas that when he asked Ali about the "creatures", he responded by saying God has created "1, species on the land, 1, species in the sea, 70 species from the Children of Adam and the people are the Children of Adam except for the Yajooj and Majooj". Some post-Cold War millenarians still identify Gog with Russia, but they now tend to stress its allies among Islamic nations, especially Iran. In the Islamic apocalyptic tradition, the end of the world would be preceded by the release of Gog and Magog, whose destruction by God in a single night would usher in the Day of Resurrection. From Wikipedia, the free encyclopedia. For the ancient oak trees of the same name, see Oaks of Albion. For other uses, see Gog disambiguation and Magog disambiguation. Maitreya Three Ages. Olivet Discourse Sheep and Goats. Four Horsemen Antichrist. Historicism Futurism. Second Coming Islamic eschatology. Kalki Kali Yuga Shiva. Death Resurrection Last Judgement. Messianism Book of Daniel Kabbalah. Li Hong. Frashokereti Saoshyant. End times Apocalypticism. Millenarianism Last Judgment. Gog and Magog Messianic Age. Contrasting beliefs. The Millennium. Biblical texts. Key terms. See also: Gates of Alexander. While Budge does not appear to comment, cf. Budge , The Life and Exploits of Alexander , p. Wallis Budge. It has a long full-title, which in shorthand reads "An exploit of Alexander.. The material is not found in the oldest Greek, Latin, Armenian, and Syriac versions. This is the aforementioned element first seen in pseudo-Methodius. According to the Greek version, Gog and Magog served the Belsyrians, whom Alexander fought them after completing his campaign against Porus. Meyer does not make this identification, and suspects a corruption of mons Caspius etc. It belongs in the Arthurian cycle. Westminster John Knox. The Book of Revelation. Berossus and Genesis, Manetho and Exodus: Hellenistic Histories and the Date of the Pentateuch. Hassell Moody Press. Daniel; Duvall, J. Scott; Pate, C. Marvin Since then many reviews repeatedly asserted there was no evidence of any effect of tamoxifen in improving survival of HCC patients [ 4 - 9 ]. Recently, the lack of a survival advantage was further confirmed by a French trial with HCC patients randomly assigned tamoxifen or supportive care alone [ 10 ]. However, following a post-hoc unplanned subgroup analysis, the Authors suggested that tamoxifen might be effective in a population of patients without major hepatic insufficiency, i. The aim of this paper is to externally validate the hypothesis of Barbare et al. The methods of the CLIP-1 trial have been detailed elsewhere [ 1 ]. CLIP-1 multicenter randomised trial had a pragmatic approach with large and simple inclusion criteria: Differently from other studies, this trial was not limited to patients with advanced disease, thus we had the opportunity to assess the possible efficacy of treatment with tamoxifen even in potentially curable subjects [ 3 ]. Overall subjects entered the study from 30 Italian institutions and were evaluable for the analysis, assigned to the tamoxifen arm, and to the control arm. Overall survival was the only endpoint of the trial and analyses were performed according to an intention-to-treat basis. Survival curves were drawn by the Kaplan-Meier method and compared by the logrank test. CLIP score was estimated as reported before [ 11 , 12 ], using Child-Pugh stage, tumor morphology, alpha fetoprotein AFP and portal vein thrombosis as score components. Similarly two subgroups of the CLIP score were obtained combining together the patients at better prognosis scores 0 or 1 and at worse prognosis scores equal to or greater than 2 or unknown. Distributions of baseline variables by treatment arm, according to prognostic Okuda subgroups. Distributions of baseline variables by treatment arm, according to prognostic CLIP subgroups. Overall baseline variables were well balanced between the two treatment arms. As expected, more potentially curative treatments surgery or percutaneous ethanol injection were observed in the subgroup with the better prognosis. In the first subgroup median survival times was equal to Of course, in patients with Okuda stage III or unknown, prognosis was much worse, median survival times being equal to 8. In the first subgroup median survival times were equal to In this paper we report a failed attempt to validate the Barbare's hypothesis [ 10 ] that tamoxifen might be effective in patients with better prognosis and confirm the previous evidence that there is no survival advantage for treating HCC patients with tamoxifen in addition to supportive therapy. Because of the broad eligibility criteria applied in the CLIP-1 trial, we had already tested possible survival differences within subgroups defined by locoregional treatment [ 3 ]. Because of the strict correlation between prognosis and locoregional treatment, the present lack of significance was expected. We also tested the same hypothesis in subgroups defined according to the CLIP score, that currently is the most widely accepted and validated prognostic score for HCC [ 11 , 12 ]. Our results substantiate the criticism against subgroup analyses, even more urgently when they are not previously planned. In multiple subgroup analyses both more false negative results, due to the smaller size of the groups, and more false positive results, due to multiple comparisons, are expected. Exploring data in search for differences possibly depending on certain baseline characteristics may be acceptable on its own, but subgroup findings must not be over-interpreted [ 13 ]. Although the power is usually limited, only statistical tests of interaction should be performed rather than subgroup-specific tests. Anyway, the interpretation strictly depends on whether findings are biologically plausible, how many analyses are done, whether they are planned ahead and how much strong is the statistical evidence, still being aware that most subgroup claims tend to exaggerate the truth [ 13 , 14 ]. Often, it is enough to correct for multiple testing so that results are no more statistically significant and conclusions not sounded; as would have been the case in the trial recently reported by Barbare et al [ 10 ]. Although Barbare et al..

Overall subjects entered the study from 30 Italian institutions and were evaluable for the analysis, assigned to the tamoxifen G og clip1, and to the control arm. Overall survival was the only endpoint of the trial and analyses were performed according to an intention-to-treat basis. Survival curves were drawn by the Kaplan-Meier method and compared by the logrank test. CLIP score was estimated as reported click [ 1112 ], using Child-Pugh stage, tumor morphology, alpha fetoprotein AFP and portal vein thrombosis as score components.

Similarly two subgroups of the CLIP score were obtained combining together the patients at better prognosis scores 0 or 1 and at worse prognosis scores equal to or greater than 2 or unknown.

Distributions of baseline variables by treatment arm, according to prognostic Okuda subgroups. Distributions of baseline variables by treatment arm, according to prognostic CLIP subgroups. Overall baseline variables were well balanced between the two treatment arms.

As expected, more potentially curative treatments surgery or percutaneous ethanol injection were observed in the subgroup with the better prognosis. In the first subgroup median survival times was equal to Of course, in patients with Okuda stage III or unknown, prognosis was much worse, median survival times being equal to 8.

In the first subgroup median survival times were equal to In this paper we report a failed attempt to validate the Barbare's hypothesis [ 10 ] that tamoxifen might be effective in patients with better prognosis and confirm the previous evidence that there is no survival advantage for treating HCC patients with tamoxifen in addition to supportive therapy.

Because of the broad eligibility criteria applied in the CLIP-1 trial, we G og clip1 already tested possible survival differences within subgroups defined by locoregional treatment [ 3 ]. Because of the strict correlation between prognosis and locoregional treatment, the present lack of significance was expected.

We also tested the same hypothesis in subgroups defined according G og clip1 the CLIP score, that currently is the most widely accepted G og clip1 validated prognostic score for HCC [ 1112 ]. Our results substantiate the criticism against subgroup analyses, even more urgently when they are not previously planned. In multiple subgroup analyses both more false negative results, due to the smaller size of the groups, and more false positive results, due to multiple comparisons, are expected.

Exploring data in search for G og clip1 possibly depending on certain baseline characteristics may be acceptable on its own, but subgroup findings must not be G og clip1 [ 13 ]. Although the power is usually limited, only statistical tests of interaction should be performed rather than subgroup-specific tests. Anyway, the interpretation strictly depends on whether G og clip1 are biologically plausible, how many analyses are done, whether they are planned ahead G og clip1 how much strong is the statistical evidence, still being aware G og clip1 most subgroup claims tend to exaggerate the truth [ 1314 ].

Often, it is enough to correct for multiple testing so that results are no more statistically significant and conclusions not sounded; as would have been the case in the trial recently reported by Barbare et al [ 10 ].

Although Barbare et al. That conclusion brought about G og clip1 report, but we failed to substantiate it. In conclusion, we believe G og clip1 the story of tamoxifen G og clip1 HCC was definitively written; to date, neither further trials are warranted with this drug in HCC nor G og clip1 use in clinical practice should be considered because of its clear lack of efficacy. However, AIRC had no role in design, analysis and interpretation of reported data.

Tube Fingering Watch PORN Videos Muslim Saxxx. Featured Game. Take this personality quiz to find out which Web Warrior fits you best! Hazards at Horizon High. Create Your Own Web Warrior. Laboratory Lockdown. Venom's Vengeance. Green Goblin Havoc. Iron Spider Ultimate Spider-Man. Featured Comic. Super Hero Adventures: Marvel and the Teleporting Dog Part 2: More Spider-Man Comics. Marvel and the Teleporting Dog Part 1: The Spider-Doctor Part 2: The Spider-Doctor Part 1: Eusebius frequently identified Gog and Magog with the Romans and their emperor. As one nomadic people followed another on the Eurasian steppes, so the identification of Gog and Magog shifted. In the 9th and 10th centuries these kingdoms were identified by some with the lands of the Khazars , a Turkic people who had converted to Judaism and whose empire dominated Central Asia—the 9th-century monk Christian of Stavelot referred to Gazari, said of the Khazars that they were "living in the lands of Gog and Magog" and noted that they were "circumcised and observing all [the laws of] Judaism". After the Khazars came the Mongols , seen as a mysterious and invincible horde from the east who destroyed Muslim empires and kingdoms in the early 13th century; kings and popes took them for the legendary Prester John , marching to save Christians from the Saracens , but when they entered Poland and Hungary and annihilated Christian armies a terrified Europe concluded that they were "Magogoli", the offspring of Gog and Magog, released from the prison Alexander had constructed for them and heralding Armageddon. Europeans in Medieval China reported findings from their travels to the Mongol Empire. The Tartar Relation , an obscure account of Friar Carpini's s journey to Mongolia, is unique in alleging that these Caspian Mountains in Mongolia, "where the Jews called Gog and Magog by their fellow countrymen are said to have been shut in by Alexander", were moreover purported by the Tartars to be magnetic, causing all iron equipment and weapons to fly off toward the mountains on approach. In fact, Gog and Magog were held by the Mongol to be their ancestors, at least by some segment of the population. As traveler and Friar Riccoldo da Monte di Croce put it in c. Some time around the 12th century, the Ten Lost Tribes of Israel came to be identified with Gog and Magog; [88] possibly the first to do so was Petrus Comestor in Historica Scholastica c. While the confounding Gog and Magog as confined Jews was becoming commonplace, some, like Riccoldo or Vincent de Beauvais remained skeptics, and distinguished the Lost Tribes from Gog and Magog. He also addressed many minds Westerners or otherwise [93] being credulous of the notion that Mongols might be Captive Jews, but after weighing the pros and cons, he concluded this was an open question. The Flemish Franciscan friar William of Rubruck , who was first-hand witness to Alexander's supposed wall in Derbent on the shores of the Caspian Sea in , [w] identified the people the walls were meant to fend off only vaguely as "wild tribes" or "desert nomads", [x] [97] but one researcher made the inference Rubruck must have meant Jews, [y] and that he was speaking in the context of "Gog and Magog". The author of the Travels of Sir John Mandeville , a 14th-century best-seller, said he had found these Jews in Central Asia where as Gog and Magog they had been imprisoned by Alexander, plotting to escape and join with the Jews of Europe to destroy Christians. He agrees to build it for them, but warns that when the time comes Last Age , Allah will remove the barrier and Yajuj and Majuj will swarm through. The early Muslim traditions were summarised by Zakariya al-Qazwini d. Gog and Magog, he says, live near to the sea that encircles the Earth and can be counted only by God; they are only half the height of a normal man, with claws instead of nails and a hairy tail and huge hairy ears which they use as mattress and cover for sleeping. They break for the night saying tomorrow we will finish, and each night God restores it. Then one day, as they stop scratching for the night, one will say tomorrow we will finish God Willing, and in the morning, it is not restored as with everything night. When they do break through they will be so numerous that "their vanguard is in Syria and their rear in Khorasan ". Various nations and peoples in history were identified as Ya'juj and Ma'juj. At one point, it was the Turks, who threatened Baghdad and northern Iran; [] later, when the Mongols destroyed Baghdad in , it was they who were Gog and Magog. It has been narrated from Ibn Abbas that when he asked Ali about the "creatures", he responded by saying God has created "1, species on the land, 1, species in the sea, 70 species from the Children of Adam and the people are the Children of Adam except for the Yajooj and Majooj". Some post-Cold War millenarians still identify Gog with Russia, but they now tend to stress its allies among Islamic nations, especially Iran. In the Islamic apocalyptic tradition, the end of the world would be preceded by the release of Gog and Magog, whose destruction by God in a single night would usher in the Day of Resurrection. From Wikipedia, the free encyclopedia. For the ancient oak trees of the same name, see Oaks of Albion. For other uses, see Gog disambiguation and Magog disambiguation. Maitreya Three Ages. Olivet Discourse Sheep and Goats. Four Horsemen Antichrist. Historicism Futurism. Second Coming Islamic eschatology. Kalki Kali Yuga Shiva. Death Resurrection Last Judgement. Messianism Book of Daniel Kabbalah. Li Hong. Frashokereti Saoshyant. End times Apocalypticism. Millenarianism Last Judgment. Gog and Magog Messianic Age. Contrasting beliefs. The Millennium. Biblical texts. Key terms. See also: Gates of Alexander. While Budge does not appear to comment, cf. Budge , The Life and Exploits of Alexander , p. Wallis Budge. It has a long full-title, which in shorthand reads "An exploit of Alexander.. The material is not found in the oldest Greek, Latin, Armenian, and Syriac versions. This is the aforementioned element first seen in pseudo-Methodius. According to the Greek version, Gog and Magog served the Belsyrians, whom Alexander fought them after completing his campaign against Porus. Meyer does not make this identification, and suspects a corruption of mons Caspius etc. It belongs in the Arthurian cycle. Westminster John Knox. The Book of Revelation. Berossus and Genesis, Manetho and Exodus: Hellenistic Histories and the Date of the Pentateuch. Hassell Moody Press. Daniel; Duvall, J. Scott; Pate, C. Marvin Dictionary of Biblical Prophecy and End Times. The prophetic literature: John Knox Press. Mohr Siebeck. In Dunn, James D. Eerdmans Commentary on the Bible. The Shengold Jewish Encyclopedia. Rockville, Maryland: Schreiber Publishing. In Wolfson, Elliot R. My Old Maps. Exploring data in search for differences possibly depending on certain baseline characteristics may be acceptable on its own, but subgroup findings must not be over-interpreted [ 13 ]. Although the power is usually limited, only statistical tests of interaction should be performed rather than subgroup-specific tests. Anyway, the interpretation strictly depends on whether findings are biologically plausible, how many analyses are done, whether they are planned ahead and how much strong is the statistical evidence, still being aware that most subgroup claims tend to exaggerate the truth [ 13 , 14 ]. Often, it is enough to correct for multiple testing so that results are no more statistically significant and conclusions not sounded; as would have been the case in the trial recently reported by Barbare et al [ 10 ]. Although Barbare et al. That conclusion brought about this report, but we failed to substantiate it. In conclusion, we believe that the story of tamoxifen in HCC was definitively written; to date, neither further trials are warranted with this drug in HCC nor any use in clinical practice should be considered because of its clear lack of efficacy. However, AIRC had no role in design, analysis and interpretation of reported data. BMC Cancer. Published online Jul Bruno Daniele 3 G. Corresponding author. Ciro Gallo: Received May 4; Accepted Jul This article has been cited by other articles in PMC. Abstract Background Large randomised clinical trials and systematic reviews substantiate that tamoxifen is ineffective in improving survival of patients with hepatocellular carcinoma HCC. Methods We used the updated database of the phase 3 randomised CLIP-1 trial that compared tamoxifen with supportive therapy. Conclusion The recent suggestion that tamoxifen might be effective in the subgroup of patients with better prognosis is not supported by a reanalysis of the CLIP-1 trial. Background At the end of '90, large randomised clinical trials showed the ineffectiveness of tamoxifen in the treatment of hepatocellular carcinoma HCC both in advanced [ 1 , 2 ] and potentially curable patients [ 3 ]. Table 1 Distributions of baseline variables by treatment arm, according to prognostic Okuda subgroups. Open in a separate window. Table 2 Distributions of baseline variables by treatment arm, according to prognostic CLIP subgroups. Figure 1. Figure 2. Figure 3. Figure 4. Discussion In this paper we report a failed attempt to validate the Barbare's hypothesis [ 10 ] that tamoxifen might be effective in patients with better prognosis and confirm the previous evidence that there is no survival advantage for treating HCC patients with tamoxifen in addition to supportive therapy. Conclusion In conclusion, we believe that the story of tamoxifen in HCC was definitively written; to date, neither further trials are warranted with this drug in HCC nor any use in clinical practice should be considered because of its clear lack of efficacy. Competing interests The author s declare that they have no competing interests. All authors read and approved the final manuscript..

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Marvel and the Teleporting Dog Part 1: The Spider-Doctor Part 2: They break for the night saying tomorrow we will finish, and each G og clip1 God restores it. Then G og clip1 day, as they stop scratching for the night, one will say tomorrow we will finish God Willing, and in the morning, it is not restored as with everything night.

When they do break through they will be so numerous that "their vanguard is in Syria and their rear in Khorasan ". Various nations and peoples in history were identified as Ya'juj and Ma'juj. At one point, it was the Turks, who threatened Baghdad and northern Iran; [] later, when the G og clip1 destroyed Baghdad init was they who were Gog and Magog.

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It has been narrated from Ibn Abbas that when he asked Ali about the read article, he responded by saying God has created "1, species on the land, 1, species in the sea, 70 species from the Children of Adam and the people are the Children of Adam except for the Yajooj and Majooj". Some post-Cold War millenarians G og clip1 identify Gog with Russia, but they now tend to stress its allies among Islamic nations, especially Iran.

In the Islamic apocalyptic tradition, the G og clip1 of the world would be preceded by G og clip1 release of Gog and Magog, whose destruction by God in a single night would usher in the Day of Resurrection.

From Wikipedia, the free encyclopedia. For the ancient oak trees of the same name, see Oaks of Albion. For other uses, see Gog disambiguation and Magog disambiguation. Maitreya Three Ages. Olivet Discourse Sheep and Goats. Four Horsemen Antichrist. Historicism Futurism.

Gog and Magog

Second Coming Islamic G og clip1. Kalki Kali Yuga Shiva. Death Resurrection Last Judgement. Messianism G og clip1 of Daniel Kabbalah. Li Hong. Frashokereti Saoshyant. End times G og clip1. Millenarianism Last Judgment. Gog and Magog Messianic Age.

Contrasting beliefs. The Millennium. Biblical texts. Key terms. See also: Gates of Alexander. While Budge does not appear to comment, cf. BudgeThe Life and Exploits of Alexanderp. Wallis Budge. It has a long full-title, which in shorthand reads "An exploit of Alexander. The material is not found in the oldest Greek, Latin, Armenian, and Syriac versions. This is the aforementioned element first G og clip1 in Tailspin hentai doujin. According to the Greek version, Gog and Magog served the Belsyrians, whom Alexander fought them after completing his campaign against Porus.

Meyer does not make this identification, and suspects a corruption of mons Caspius etc. It belongs in the Arthurian cycle. Westminster John Knox. The Book of Revelation. Berossus and Genesis, Manetho and Exodus: Hellenistic Histories and the Date of the Pentateuch.

Hassell Moody Press.

G og clip1

Daniel; G og clip1, J. Scott; Pate, C. Marvin Dictionary of Biblical Prophecy and End Times. The prophetic literature: John Knox Press. Mohr Siebeck. In Dunn, James D. Eerdmans Commentary on the Bible. The Shengold Jewish Encyclopedia.

Sexting babes Watch Porn Movies biggestdicksinporn. Super Hero Adventures: Marvel and the Teleporting Dog Part 2: More Spider-Man Comics. Marvel and the Teleporting Dog Part 1: The Spider-Doctor Part 2: The Spider-Doctor Part 1: Marvel Tails: Spectacular Spider-Ham Part 2: Spectacular Spider-Ham Part 1: Ultimate Spider-Man: Spider-Verse Spider-man Marvel Adventures: Spectacular Part Amazing Ross , New York: Kraus International Publication, pp. Gog of Magog: Reuse of Scripture and Compositional Technique in Ezekiel 38— Van Donzel, Emeri J. Sallam's Quest for Alexander's Wall. Westrem, Scott D. Tomasch, Sylvia; Sealy, Gilles, eds. Text and Territory: Geographical Imagination in the European Middle Ages. University of Pennsylvania Press. Encyclopedias Lust, J. Dictionary of deities and demons in the Bible. Lust, J. Encyclopaedia Judaica. Granite Hill Publishers. Biblical studies Blenkinsopp, Joseph A History of Prophecy in Israel revised and enlarged ed. Block, Daniel I. The Book of Ezekiel: Literary Armstrong, Edward C. The Medieval French Roman d'Alexandre. Bietenholz, Peter G. Historia and Fabula: Cambridge University Press. Meyer, Paul Stoneman, Richard tr. The Greek Alexander Romance. Geography and ethnography Brook, Kevin A The Jews of Khazaria. Gow, Andrew Colin The Red Jews: Antisemitism in an Apocalyptic Age, — Marshall, Robert Storm from the East: University of California Press. Massing, Michel , Levenson, Jay A. The World of the Catalan Atlas" , Circa Murray, pp. Rockhill, William Woodville , ed. Modern apocalyptic thought Cook, David Contemporary Muslim Apocalyptic Literature. Syracuse University Press. Filiu, Jean-Pierre Apocalypse in Islam. Kyle, Richard G. Apocalyptic Fever: End-Time Prophecies in Modern America. Wipf and Stock Publishers. Wessels, Anton The Torah, the Gospel, and the Qur'an: People and things in the Quran. The names are sorted alphabetically. Standard form: Descendants of Noah in Genesis Elam Ashur Arpachshad Lud Aram. Cush Mizraim Phut Canaan. Retrieved from " https: Hidden categories: Pages using citations with accessdate and no URL Articles containing Hebrew-language text Articles containing Arabic-language text Articles containing Syriac-language text Commons category link from Wikidata Wikipedia articles needing clarification from November Namespaces Article Talk. Views Read Edit View history. In other projects Wikimedia Commons. This page was last edited on 16 April , at By using this site, you agree to the Terms of Use and Privacy Policy. Part of a series on. Buddhist Maitreya Three Ages. Hindu Kalki Kali Yuga Shiva. Jewish Messianism Book of Daniel Kabbalah. Taoist Li Hong. Zoroastrian Frashokereti Saoshyant. Eschatological views. Pseudepigrapha 1 Enoch 2 Esdras. Christianity portal. Wikimedia Commons has media related to Gog and Magog. Although the power is usually limited, only statistical tests of interaction should be performed rather than subgroup-specific tests. Anyway, the interpretation strictly depends on whether findings are biologically plausible, how many analyses are done, whether they are planned ahead and how much strong is the statistical evidence, still being aware that most subgroup claims tend to exaggerate the truth [ 13 , 14 ]. Often, it is enough to correct for multiple testing so that results are no more statistically significant and conclusions not sounded; as would have been the case in the trial recently reported by Barbare et al [ 10 ]. Although Barbare et al. That conclusion brought about this report, but we failed to substantiate it. In conclusion, we believe that the story of tamoxifen in HCC was definitively written; to date, neither further trials are warranted with this drug in HCC nor any use in clinical practice should be considered because of its clear lack of efficacy. However, AIRC had no role in design, analysis and interpretation of reported data. BMC Cancer. Published online Jul Bruno Daniele 3 G. Corresponding author. Ciro Gallo: Received May 4; Accepted Jul This article has been cited by other articles in PMC. Abstract Background Large randomised clinical trials and systematic reviews substantiate that tamoxifen is ineffective in improving survival of patients with hepatocellular carcinoma HCC. Methods We used the updated database of the phase 3 randomised CLIP-1 trial that compared tamoxifen with supportive therapy. Conclusion The recent suggestion that tamoxifen might be effective in the subgroup of patients with better prognosis is not supported by a reanalysis of the CLIP-1 trial. Background At the end of '90, large randomised clinical trials showed the ineffectiveness of tamoxifen in the treatment of hepatocellular carcinoma HCC both in advanced [ 1 , 2 ] and potentially curable patients [ 3 ]. Table 1 Distributions of baseline variables by treatment arm, according to prognostic Okuda subgroups. Open in a separate window. Table 2 Distributions of baseline variables by treatment arm, according to prognostic CLIP subgroups. Figure 1. Figure 2. Figure 3. Figure 4. Discussion In this paper we report a failed attempt to validate the Barbare's hypothesis [ 10 ] that tamoxifen might be effective in patients with better prognosis and confirm the previous evidence that there is no survival advantage for treating HCC patients with tamoxifen in addition to supportive therapy. Conclusion In conclusion, we believe that the story of tamoxifen in HCC was definitively written; to date, neither further trials are warranted with this drug in HCC nor any use in clinical practice should be considered because of its clear lack of efficacy. Competing interests The author s declare that they have no competing interests. All authors read and approved the final manuscript. Pre-publication history The pre-publication history for this paper can be accessed here:.

Rockville, Maryland: Schreiber Publishing. In Wolfson, Elliot R. My Old Maps. Retrieved The Church in the Shadow of the Mosque: Christians and Muslims in the World of Islam. Princeton, NJ: Princeton University Press. Chronology of Prophetic Events. Ta-Ha G og clip1 Ltd.

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Snapsext delete Watch XXX Movies Tube Lasbian. Featured Video. See Spidey's ally turn on him. Web Warriors" Videos. Part Four" - Clip 1 0: Contest of Champions: Part Three - Clip 1 1: Part Two - Clip 1 0: Part One - Clip 1 0: Part Four" Clip 1 1: Part Three" Clip 1 1: Part Two" Clip 1 1: Part One" Clip 2 1: Part One" Clip 1 1: Part Three" Clip 1: Part Two" Clip 1: According to the Greek version, Gog and Magog served the Belsyrians, whom Alexander fought them after completing his campaign against Porus. Meyer does not make this identification, and suspects a corruption of mons Caspius etc. It belongs in the Arthurian cycle. Westminster John Knox. The Book of Revelation. Berossus and Genesis, Manetho and Exodus: Hellenistic Histories and the Date of the Pentateuch. Hassell Moody Press. Daniel; Duvall, J. Scott; Pate, C. Marvin Dictionary of Biblical Prophecy and End Times. The prophetic literature: John Knox Press. Mohr Siebeck. In Dunn, James D. Eerdmans Commentary on the Bible. The Shengold Jewish Encyclopedia. Rockville, Maryland: Schreiber Publishing. In Wolfson, Elliot R. My Old Maps. Retrieved The Church in the Shadow of the Mosque: Christians and Muslims in the World of Islam. Princeton, NJ: Princeton University Press. Chronology of Prophetic Events. Ta-Ha Publishers Ltd. Tauris Publishers. K A History of Scandinavia: Norway, Sweden, Denmark, Finland, and Iceland. University of Minnesota Press. Painter, ed. Marco Polo and the Encounter of East and West. University of Toronto Press. Universidad de Alicante. Dictionary of Islam. New Delhi: Asian Educational Services. Hakluyt Society. Al-Kafi Volume 8 ed. Islamic Seminary Incorporated. Prophecy Belief in Modern Culture. Belknap Press. Religion and the State in Russia and China. Simon and Schuster. Monographs Anderson, Andrew Runni Alexander's Gate, Gog and Magog: And the Inclosed Nations. Cambridge, Massachusetts: Mediaeval Academy of America. Gog and Magog: Ezekiel 38—39 as Pre-text for Revelation 19,17—21 and 20,7— Buitenwerf, Rieuwerd In de Jonge, H. The Book of Ezekiel and its Influence. Ashgate Publishing. Essays in Honour of David J. Ross , New York: Kraus International Publication, pp. Gog of Magog: Reuse of Scripture and Compositional Technique in Ezekiel 38— Van Donzel, Emeri J. Sallam's Quest for Alexander's Wall. Westrem, Scott D. Tomasch, Sylvia; Sealy, Gilles, eds. Text and Territory: Geographical Imagination in the European Middle Ages. University of Pennsylvania Press. Encyclopedias Lust, J. Dictionary of deities and demons in the Bible. Lust, J. Survival differences were tested by the Log-rank test. Median survival times were equal to The recent suggestion that tamoxifen might be effective in the subgroup of patients with better prognosis is not supported by a reanalysis of the CLIP-1 trial. Tamoxifen should no longer be considered for the treatment of HCC patients and future trials of medical treatment should concentrate on different drugs. At the end of '90, large randomised clinical trials showed the ineffectiveness of tamoxifen in the treatment of hepatocellular carcinoma HCC both in advanced [ 1 , 2 ] and potentially curable patients [ 3 ]. Since then many reviews repeatedly asserted there was no evidence of any effect of tamoxifen in improving survival of HCC patients [ 4 - 9 ]. Recently, the lack of a survival advantage was further confirmed by a French trial with HCC patients randomly assigned tamoxifen or supportive care alone [ 10 ]. However, following a post-hoc unplanned subgroup analysis, the Authors suggested that tamoxifen might be effective in a population of patients without major hepatic insufficiency, i. The aim of this paper is to externally validate the hypothesis of Barbare et al. The methods of the CLIP-1 trial have been detailed elsewhere [ 1 ]. CLIP-1 multicenter randomised trial had a pragmatic approach with large and simple inclusion criteria: Differently from other studies, this trial was not limited to patients with advanced disease, thus we had the opportunity to assess the possible efficacy of treatment with tamoxifen even in potentially curable subjects [ 3 ]. Overall subjects entered the study from 30 Italian institutions and were evaluable for the analysis, assigned to the tamoxifen arm, and to the control arm. Overall survival was the only endpoint of the trial and analyses were performed according to an intention-to-treat basis. Survival curves were drawn by the Kaplan-Meier method and compared by the logrank test. CLIP score was estimated as reported before [ 11 , 12 ], using Child-Pugh stage, tumor morphology, alpha fetoprotein AFP and portal vein thrombosis as score components. Similarly two subgroups of the CLIP score were obtained combining together the patients at better prognosis scores 0 or 1 and at worse prognosis scores equal to or greater than 2 or unknown. Distributions of baseline variables by treatment arm, according to prognostic Okuda subgroups. Distributions of baseline variables by treatment arm, according to prognostic CLIP subgroups. Overall baseline variables were well balanced between the two treatment arms. As expected, more potentially curative treatments surgery or percutaneous ethanol injection were observed in the subgroup with the better prognosis. In the first subgroup median survival times was equal to Of course, in patients with Okuda stage III or unknown, prognosis was much worse, median survival times being equal to 8. In the first subgroup median survival times were equal to In this paper we report a failed attempt to validate the Barbare's hypothesis [ 10 ] that tamoxifen might be effective in patients with better prognosis and confirm the previous evidence that there is no survival advantage for treating HCC patients with tamoxifen in addition to supportive therapy. Because of the broad eligibility criteria applied in the CLIP-1 trial, we had already tested possible survival differences within subgroups defined by locoregional treatment [ 3 ]. Because of the strict correlation between prognosis and locoregional treatment, the present lack of significance was expected. We also tested the same hypothesis in subgroups defined according to the CLIP score, that currently is the most widely accepted and validated prognostic score for HCC [ 11 , 12 ]. Our results substantiate the criticism against subgroup analyses, even more urgently when they are not previously planned. In multiple subgroup analyses both more false negative results, due to the smaller size of the groups, and more false positive results, due to multiple comparisons, are expected..

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